Hall has won many awards for her portrayal of Marlena. Deidre won two Best Actress Soapy Awards in 1982 and 1983. She has won three Soap Opera Digest Awards for Outstanding Lead Actress in 1984, 1985, and 1995. Deidre was the first recipient of the Outstanding Contribution by an Actress/Actor Award in 1986. Hall also received an award with Drake Hogestyn in 2005 for Favorite Couple: John and Marlena. Deidre was also voted Best Actress twice by the Soap Opera Update Awards in 1994 and 1995. She has been nominated for a Daytime Emmy three times, but hasn't won.
The third of five children, Hall and her twin sister, Andrea Hall, were born in Milwaukee, Wisconsin and raised in Lake Worth, Florida. At age 12, Hall was elected Junior Orange Bowl Queen. She is a graduate of Lake Worth High School, Class of 1965, and studied psychology before sidetracking into acting.
Along with her sister, Andrea, Hall appeared in press materials for the 1952 Hudson Twin-H-Power engine. In her late teens, Hall traveled to Los Angeles for the summer - while attending Palm Beach Junior College - and there she landed some modeling jobs and commercials through an agent. Quickly, she began appearing in television shows, thinking it was temporary until landing a serious career as a psychologist. In a later interview, she recalled that one day, she realized that acting was her serious career.
In the 1970s, she portrayed the superheroine Electra Woman in Electra Woman and Dyna Girl, a Sid and Marty Krofft children's show that aired on Saturday mornings.
Hall appeared on a number of shows, including Emergency! (as Nurse Sally Lewis in the first two seasons), and The Young and the Restless (as Barbara Anderson), before joining Days of Our Lives in 1976 as Dr. Marlena Evans. In an interview, Hall said that she thought that she would have no chance to land the role of Marlena, considering that she was unsure about a career in soap operas, as well as having to compete against established soap opera veterans for the role. Hall was cast, though, and the role skyrocketed her to fame, which was proved by fan protests when a 1979 NBC promo hinted that Hall's character would be killed off. Two separate daytime television magazines named Hall the best soap actress of 1983.
In 1986, Hall began playing Jesse Witherspoon on the family drama, Our House, which ran for two seasons on NBC. Wilford Brimley, who is thirteen years older than Hall, played her father-in-law in the series; Chad Allen, her son; Shannen Doherty, her older daughter. Hall initially reacted without concern on playing on two television series at a time, explaining that she filmed Our House on weekdays while taping Days of our Lives on Saturdays. However, Hall exited Days of our Lives in 1987 when it became too difficult to co-ordinate her prime time and daytime schedules. Our House was cancelled in 1988, though she did not immediately return to the soap opera.
Instead, Hall continued to make guest appearances on a variety of prime time shows until March 1991, when she made a return to Days of our Lives. This decision was a result of a request by producer Ken Corday, who hoped her return would have influence on the low ratings. According to the actress, she was approached to play a new character, but she refused and insisted on portraying Marlena, with a contract for six months only. Producers were reluctant to give into Hall's requests, fearing that the fans would leave after six months when Hall left. However, Hall remained on contract with the show for eighteen more years until January 24, 2009, when she was terminated because of budget cuts mandated by NBC. Her salary on Days of Our Lives was in the range of $60,000.00 per month, much higher than most other daytime serial actors. Hall has appeared in more than 3,800 episodes.
In 1995, Hall produced and starred in Never Say Never: The Deidre Hall Story, a made-for-TV movie about her personal struggles to become a mother. Longtime Days co-star Suzanne Rogers is featured in the program.
Since at least early 2009, Hall has occasionally guest-hosted Clout, a talk radio program syndicated through Air America Media. In 2010, Hall and her writing partner Lynne Bowman wrote "Deidre Hall's Kitchen Closeup." In 2011 Hall guest starred on the season finale of Lifetime's Drop Dead Diva. She and Drake Hogestyn reprised their roles as Marlena Evans and John Black on September 26, 2011.
Hall received a star on the Walk of Fame in 2014.